Our Thinking

Characterization of Chronic Lymphocytic Leukemia / Small Lymphocytic Lymphoma (CLL/SLL) in Shanghai, China: Molecular and Cytogenetic characteristics, IgV gene restriction and hypermutation patterns.
Irons RD, Le A, Bao L, Zhu X, Ryder J, Wang XQ, Ji M, Chen Y, Wu X, Lin G.
Leukemia Research. 2009 May 8. Epub ahead of print

Adult precursor B lymphoblastic leukemia in Shanghai, China: Characterization of phenotype, cytogenetics and outcome for 137 consecutive cases.
Bao, L. Gross, SA, Ryder, J, Wang, X-Q, Ji, M, Chen, Y., Yang, Y, Zhu, S, and Irons, RD
International Journal of Hematology. 2009 Sep;89(4):431-7. Epub 2009 Mar 26.

A Prospective Study of 728 Cases of Non-Hodgkin Lymphoma from a Single Laboratory in Shanghai,China. 
Gross SA, Zhu XZ, Bao L, Ryder J, Le A, Chen Y, Wang XQ and Irons RD. (2008)
International Journal of Hematology. 2008 Sep;88(2):165-73. Epub 2008 Jul 23.

Dithiocarbamates and viral IL-10 collaborate in the immortalization and evasion of immune response in EBV-infected human B lymphocytes. 
Irons RD and Le AT
Chemico-Biological Interactions. 2008 Mar 10;172(1):81-92. Epub 2007 Nov 22.

The TNF-α 238A polymorphism confers susceptibility to persistent bone marrow dysplasia following chronic exposure to benzene. 
Lv L, Kerzic P, Lin G, Schnatter AR, Bao L, Yang Y, Zou H, Fu H, Ye X, Gross SA, Armstrong TW and Irons RD
 Leukemia Research. 2007 Nov;31(11):1479-85. Epub 2007 Mar 23.

Aggressive NK Cell Leukemia: Report of a Chinese Series and Review of the Literature.
Ryder J, Wang X, Bao L, Gross SA, Fu H, Irons RD
International Journal of Hematology. 2007 Jan;85(1):18-25.

Prevalence of MDS subtypes in Shanghai, China: A comparison of the World Health Organization and French American British Classifications. 
Irons RD, Wang X-Q, Gross SA, Bao L, Ryder J, Chen Y, Chen H, Sun H, Zhou J, Ji M, Du X, Fu H, Lin G
Leukemia Research. 2006 Jul;30(7):769-75. Epub 2005 Dec 6.

Prospective study of 174 de novo acute myelogenous leukemias according to the WHO classification: subtypes, cytogenetic features and FLT3 mutations.  
Bao L,Wang X-Q, Ryder J, Ji M, Chen Y, Sun H, Yang Y, Du X, Kerzic PJ, Gross SA, Yao L, Lv L, Fu H, Lin G and Irons RD
European Journal of Haematology. 2006 Jul;77(1):35-45. Epub 2006 Mar 27.

PU.1 phosphorylation correlates with hydroquinone-induced alterations in myeloid differentiation and cytokine-dependent clonogenic response in human CD34+ hematopoietic progenitor cells. 
Gross, SA, Zheng JH, Le A-T, Kerzic PJ and Irons RD
Cell Biology and Toxicology. 2006 Jul;22(4):229-41. Epub 2006 Apr 26.

Chronic exposure to benzene results in a unique form of dysplasia. 
Irons RD, Lv L, Gross SA, Ye X, Bao L, Wang X-Q, Ryder J, Armstrong TW, Zhou Y, Jiao L, Le A-T, Kerzic PJ, Ni W and Fu H
Leukemia Research. 2005 Dec;29(12):1371-80. Epub 2005 Sep 23.

Hydroquinone modulates the GM-CSF signaling pathway in TF-1 cells. 
Zheng JH, Pyatt DW, Gross SA, Le A-T, Kerzic PJ and Irons RD.
Leukemia. 2004 Jul;18(7):1296-304.

Inhibition of NF-kB by hydroquinone-sensitive human bone marrow progenitor cells to TNF-a-induced apoptosis. 
Kerzic PJ,  Pyatt DW, Zheng J-H, Gross SA, Le A-T and Irons RD
Toxicology. 2003 May 3;187(2-3):127-37.

            Reprints are available upon request

Abstracts and Presentations at International Meetings

Enhancement of cytokine-induced apoptosis by benzene metabolites is unique to TNF.
Kerzic PJ, Irons, RD, Le, A-T, Gross, SA Fudan-Cinpathogen Clinical and Molecular Research Center, IBS. Society of Toxicology.
The Toxicologist. 2008; 102: S1 #346.

Lymphoid neoplasms in Shanghai, China: Relative frequency of subtypes of NHL diagnosed according to the WHO classification. 
Gross SA, Wang XQ, Ryder J, Zhu XZ, Bao L, Fu H, and Irons RD. 
Proceedings of the American Association for Cancer Research. 2006; 47: 5364.

Prognostic analysis of 166 cases with myelodysplastic syndrome diagnosed by WHO classification.” 
Wang X-Q, Irons RD, Lin G, Ji M, Du X, Bao L and Fu H. 
East China Hematology Meeting, Shanghai, China, Oct 11, 2005.

Aggressive NK cell leukemia in Shanghai, China.  
Irons RD, Chen Y, Bao L, Zhou J, Wang XQ, Ryder J, Ji J and Fu H. (2005) 
Annals of Oncology. 2005; 16, Sup 5: 515.

Benzene Poisoning in Shanghai, China: Preliminary Findings.  
Irons RD, Ye XB, Bao L, Wang XQ, Ryder J, Armstrong T, Zhou Y, Miao LZ, Gross SA and Fu H.
Munich, Germany, Oct 11, 2004.

Prevalence of MDS in Shanghai, China Using the WHO Classification. 
Irons RD, Bao L, Wang XQ, Ryder J, Ji J, Du X, Gross SA, Chen H, Chen Y, Kerzic PJ, Fu H and Lin G
Blood. 2004; 104 (11) Sup 1: 4715.

Selective inhibition of I kappa kinase (ikk) by benzene metabolites. 
Kerzic PJ, Pyatt DW, Le AT, Zheng T, Gross SA and Irons RD. 
Experimental Hematology. 2004; 32, Sup 1: 146.

Direct inhibition of I Kappa Kinase activity by benzene metabolites sensitizes bone marrow cells to cytokine-induced apoptosis. 
Kerzic P, Pyatt D, Zheng T, Le A, Gross S and Irons R. (2003) 
Toxicological Sciences. 2003; 72 (1): 1716.

Conferences
The Fudan- Cinpathogen Clinical and Molecular Research Center Hematology Conference, held in December, 2007, focused on current developments in clinical laboratory medicine in Shanghai.

  • The conference was chaired by Professor Lin Guowei, Director of the Shanghai Clinical Epidemiology Institute and Professor Ouyang Renrong, past chairman of the Chinese Hematology Society and the Shanghai Hematology Society. 
  • Physicians and clinicians from 40 Shanghai area hospitals participated.